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1

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

Klutchko, Sylvester, Blankley, C. John, Fleming, Robert W., Hinkley, Jack M., Werner, Ann E., Nordin, Ivan, Holmes, Ann, Hoefle, Milton L., Cohen, David M.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1.13 MB

english, 1986

2

Anti-Angiogenic Activity of Selected Receptor Tyrosine Kinase Inhibitors, PD166285 and PD173074: Implications for Combination Treatment with Photodynamic Therapy

Charles J. Dimitroff, Wayne Klohs, Amarnath Sharma, Paula Pera, Denise Driscoll, Jean Veith, Randall Steinkampf, Mel Schroeder, Sylvester Klutchko, Adam Sumlin, Barbara Henderson, Thomas J. Dougherty,

Journal:

Investigational New Drugs

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

3

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids

Klutchko, Sylvester, Hoefle, Milton L., Smith, Ronald D., Essenburg, Arnold D., Parker, Robert B., Nemeth, Vicki L., Ryan, Michael, Dugan, Deborah H., Kaplan, Harvey R.

Journal:

Journal of Medicinal Chemistry

Year:

1981

Language:

english

File:

PDF, 823 KB

english, 1981

4

2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Klutchko, Sylvester R., Hamby, James M., Boschelli, Diane H., Wu, Zhipei, Kraker, Alan J., Amar, Aneesa M., Hartl, Brian G., Shen, Cynthia, Klohs, Wayne D., Steinkampf, Randall W.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 404 KB

english, 1998

5

4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids (spinacines)

Sylvester Klutchko, John C. Hodges, C. John Blankley, Norman L. Colbry

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 1023 KB

1991

6

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype

Blankley, C. John, Hodges, John C., Klutchko, Sylvester R., Himmelsbach, Richard J., Chucholowski, Alexander, Connolly, Cleo J., Neergaard, Sandra J., Van Nieuwenhze, Michael S., Sebastian, Alan

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.75 MB

english, 1991

7

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Boschelli, Diane H., Wu, Zhipei, Klutchko, Sylvester R., Showalter, H. D. Hollis, Hamby, James M., Lu, Gina H., Major, Terry C., Dahring, Tawny K., Batley, Brian, Panek, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 219 KB

english, 1998

8

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

Patt, William C., Hamilton, Harriet W., Taylor, Michael D., Ryan, Michael J., Taylor, David G., Connolly, Cleo J. C., Doherty, Annette M., Klutchko, Sylvester R., Sircar, Ila

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.48 MB

english, 1992

9

Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity

Sylvester Klutchko, James M. Hamby, John C. Hodges

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 372 KB

english, 1994

10

Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4- d ]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

Klutchko, Sylvester R., Zhou, Hairong, Winters, R. Thomas, Tran, Tuan P., Bridges, Alexander J., Althaus, Irene W., Amato, Danielle M., Elliott, William L., Ellis, Paul A., Meade, Mary Ann, Roberts, B

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

11

Base rearrangement of chromone-3-carboxylic esters to 3-acyl-4-hydroxycoumarins

Klutchko, Sylvester, Shavel, John, Von Strandtmann, Maximilian

Journal:

Journal of Organic Chemistry

Year:

1974

Language:

english

File:

PDF, 280 KB

english, 1974

12

4,7-Diazaindole Derivatives

Klutchko, Sylvester, Hansen, H. Victor, Meltzer, Robert I.

Journal:

Journal of Organic Chemistry

Year:

1965

Language:

english

File:

PDF, 569 KB

english, 1965

13

Chemistry and Pharmacology of Monoamine Oxidase Inhibitors: Hydrazine Derivatives

Anderson, Floyd E., Kaminsky, Daniel., Dubnick, Bernard., Klutchko, Sylvester R., Cetenko, Wiaczeslaw A., Gylys, Jonas., Hart, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1962

Language:

english

File:

PDF, 525 KB

english, 1962

14

Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Edmunds, Jeremy J., Klutchko, Sylvester, Hamby, James M., Bunker, Amy M., Connolly, Cleo J. C., Winters, R. Thomas, Quin, John, Sircar, Ila, Hodges, John C.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.80 MB

english, 1995

15

Amino Derivatives of Pyrazine N-Oxides 1

Lutz, Wilson B., Lazarus, Sam, Klutchko, Sylvester, Meltzer, Robert I.

Journal:

Journal of Organic Chemistry

Year:

1964

Language:

english

File:

PDF, 439 KB

english, 1964

16

Isomerism in the Direct Chlorination of 2-Methylpyrazine 1a

Lutz, Wilson B., Lazarus, Sam, Klutchko, Sylvester, Meltzer, Robert I.

Journal:

Journal of Organic Chemistry

Year:

1964

Language:

english

File:

PDF, 568 KB

english, 1964

17

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation

Rao, Chetana M., Scarborough, Paula E., Kay, John, Batley, Brian, Rapundalo, Stephen, Klutchko, Sylvester, Taylor, Michael D., Lunney, Elizabeth A., Humblet, Christine C., Dunn, Ben M.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 2.33 MB

english, 1993

18

Stereospecific Synthesis of S,S-Statine and its Congeners

Klutchko, Sylvester, O'brien, Patrick, Hodges, John C.

Journal:

Synthetic Communications

Year:

1989

Language:

english

File:

PDF, 385 KB

english, 1989

19

General Rearrangement of 3-Substituted Chromones. Rearrangement to 1-Benzoxepins and 4-Chromanones

KLUTCHKO, Sylvester, von STRANDTMANN, Maximillian

Journal:

Year:

1977

File:

PDF, 194 KB

1977

20

Antifungal agents. 3. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. A divinylcyclopropane-cycloheptadiene rearrangement.

CONNOR, DAVID T., KLUTCHKO, SYLVESTER, STRANDTMANN, MAXIMILLIAN VON

Journal:

The Journal of Antibiotics

Year:

1979

Language:

english

File:

PDF, 1.51 MB

english, 1979

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